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Description
FABP4 Recombinant Rabbit mAb (S-1360-168)Product Specification Host Rabbit Antigen FABP4 Synonyms Fatty acid binding protein, adipocyte; Adipocyte lipid binding protein (ALBP); Adipocyte type fatty acid binding protein (A FABP; AFABP); Fatty acid binding protein 4 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P15090 Clone Number S 1360 168 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample 3T3 L1, rat heart Predicted
Product Specification
| Host | Rabbit |
| Antigen | FABP4 |
| Synonyms | Fatty acid-binding protein, adipocyte; Adipocyte lipid-binding protein (ALBP); Adipocyte-type fatty acid-binding protein (A-FABP; AFABP); Fatty acid-binding protein 4 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P15090 |
| Clone Number | S-1360-168 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | 3T3-L1, rat heart |
| Predicted Reactivity | Pg |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:1000-1:2000 | Hu |
| IF | 1:2000 | Hu |
Background
FABP4, also known as Adipocyte Fatty Acid Binding Protein (A-FABP) or aP2, is a small cytoplasmic protein belonging to the family of fatty acid-binding proteins (FABPs). It is widely expressed in various tissues, including adipose tissue, macrophages, small intestine, heart, and breast, with particularly high levels in adipocytes and macrophages. The primary function of FABP4 is to serve as an intracellular transporter of fatty acids. It facilitates the uptake, transport, and metabolism of fatty acids by binding to long-chain fatty acids (LCFAs) to form stable complexes. These complexes then shuttle the fatty acids to various intracellular compartments such as mitochondria, endoplasmic reticulum, or peroxisomes for processes like β-oxidation, esterification, or phospholipid synthesis. In addition to its role in fatty acid metabolism, FABP4 is also involved in regulating adipocyte differentiation and insulin sensitivity. Moreover, it plays a significant part in inflammatory responses and immune modulation.
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