SKU: 54669563742

SAMe (Designs for Health), 30 capsules

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Description

SAMe (Designs for Health), 30 capsulesDownload Patient Handout SAMe is a naturally occurring metabolite found in the human body as well as in plant and animal foods. It is the most active of all methyl donors and has been compared to ATP in its importance for the body. SAMe is naturally synthesized in humans from the amino acid methionine in the presence of the cofactors B12 and folate. SAMe is involved in the synthesis of neurotransmitters, the hormone melatonin, phospholipids, and

Download Patient Handout

SAMe is a naturally occurring metabolite found in the human body as well as in plant and animal foods. It is the most active of all methyl donors and has been compared to ATP in its importance for the body. SAMe is naturally synthesized in humans from the amino acid methionine in the presence of the cofactors B12 and folate.

SAMe is involved in the synthesis of neurotransmitters, the hormone melatonin, phospholipids, and polyamines, which control cellular growth. It is also the source of methyl groups inside the nucleus for DNA methylation, which controls gene expression and masking of genetic damage.

These capsules provide 200 mg of SAMe along with vitamins B6, B12, and folate as 5-MTHF in order to provide cofactors for the natural conversions of SAMe to L-homocysteine and then safely to L-cysteine.

As a dietary supplement, take one capsule per day, preferably on an empty stomach, or as directed by your health care practitioner.

Serving Size: One Capsule

Amount Per Serving
Vitamin B-6 ... 5mg
(as Pyridoxal-5-Phosphate)
Folate ... 170mcg DFE
(as Quatrefolic® [6S]-5-Methyltetrahydrofolate, glucosamine salt 200mcg)
Vitamin B-12 ... 50mcg
(as Methylcobalamin)
SAMe ... 200mg
(as S-Adenosyl-L-Methionine Disulfate P-Toluensulfate)

Other Ingredients: Cellulose (capsule), microcrystalline cellulose, vegetable stearate, calcium chloride anhydrous, calcium oxide.

This product does not contain gluten.

Quatrefolic® is covered by U.S. Patent No. 7, 947, 662 and is a registered trademark of Gnosis S.p.A.

NOTICE
Color, size or shape may appear different between lots.

Store at room temperature. Keep out of reach of children.

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent disease.

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SKU: 54669563742

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Kay Mac
Draper, US
★★★★★ 5
I like it
Makes my skin feel very soft. Moisturizes without making you greasy.
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Reviewed in the United States on May 30, 2026
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Jorge
Port Orchard, US
★★★★★ 5
Good Product
Lo recomiendo excelente
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Reviewed in the United States on May 28, 2026
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Carmen
New York, US
★★★★★ 5
Suavecito
Súper hidratante
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Reviewed in the United States on May 17, 2026
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Maria
Dallas, US
★★★★★ 3
Product came spilled
The product is fine. The packaging however came broken and the product had spilled all over the box.
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Reviewed in the United States on January 14, 2026
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Ankita P
Natrona Heights, US
★★★★★ 1
No No No
I had the worst nightmare using the APLB Tranexamic Acid Niacinamide Lotion. I used this product consistently for about three weeks, hoping it would help with brightening and hyperpigmentation, but instead it completely damaged my skin barrier. What started as mild irritation quickly turned into severe itching, redness, inflamed bumps, and intense skin sensitivity. Eventually, my skin developed dermatitis-like symptoms with painful inflammation, red rashes, and even slight bleeding in certain areas from constant irritation and scratching. Instead of improving, this lotion made my skin look worse — angry, inflamed, textured, and extremely reactive. The itching was unbearable, and the red bumps took a long time to calm down. If you have sensitive skin or are prone to eczema, contact dermatitis, or allergic reactions, please patch test very carefully before using this product. My experience was honestly terrible, and recovering my skin afterward took much longer than the three weeks I spent using it. (Still recovering after 2 months)
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Reviewed in the United States on May 28, 2026

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