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Description
Invivo Anti-Mouse/Human/Rat Osteopontin (SPP1) Recombinant mAbProduct Specification Host Mouse Antigen Osteopontin (SPP1) Synonyms 2AR; Bone sialoprotein 1; Calcium oxalate crystal growth inhibitor protein; Early T lymphocyte activation 1 protein; Minopontin; Secreted phosphoprotein 1 (SPP 1); Eta 1; Op; Spp 1 Location Secreted Accession P10923P10451P08721 Clone Number S 3186 Antibody Type Mouse mAb Isotype Mouse IgG1, Application WB, in vitro OPN neutralization, in vivo OPN neutralization Reactivity Hu, Ms, Rt
Product Specification
| Host | Mouse |
| Antigen | Osteopontin (SPP1) |
| Synonyms | 2AR; Bone sialoprotein 1; Calcium oxalate crystal growth inhibitor protein; Early T-lymphocyte activation 1 protein; Minopontin; Secreted phosphoprotein 1 (SPP-1); Eta-1; Op; Spp-1 |
| Location | Secreted |
| Accession | P10923、P10451、P08721 |
| Clone Number | S-3186 |
| Antibody Type | Mouse mAb |
| Isotype | Mouse IgG1, κ |
| Application | WB, in vitro OPN neutralization, in vivo OPN neutralization |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
Background
Osteopontin (OPN), encoded by the secreted phosphoprotein 1 (SPP1) gene, is a multifunctional 34-kDa matricellular glycoprotein rich in aspartic acid and serine phosphorylation sites that undergoes extensive alternative splicing and post-translational modifications (glycosylation, phosphorylation, sulfation, proteolytic cleavage) to generate multiple isoforms; it is secreted by osteoblasts, immune cells, epithelial and endothelial cells, and platelets, and it binds integrins (αvβ3, αvβ1, αvβ5, CD44 variants) and CD44 itself to regulate cell adhesion, migration, survival, and matrix remodeling, thereby orchestrating physiological processes such as bone mineralization, wound healing, and angiogenesis, while pathologically promoting chronic inflammation, tumor metastasis, fibrosis, and vascular calcification through activation of PI3K/Akt, MAPK/ERK, NF-κB, and TGF-β signaling cascades; its circulating levels rise in response to injury, infection, obesity, and cancer, making it a prognostic biomarker and therapeutic target across cardiovascular, renal, autoimmune, and neoplastic diseases.
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