Pay in installments of $70.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 22 - Jul 27
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Biotinylated SLAMF7/CRACC/CD319 Avi&His Tag Protein, HumanProduct Specification Species Human Synonyms CS1UNQ576 PRO1138Novel Ly9SLAM Family Member 7Membrane Protein FOAP 12CD2 Subset 1Protein 19ACD2 Like Receptor Activating Cytotoxic CellsCD2 Like Receptor Activating Cytotoxic Cells19A24 Protein19ACD319 AntigenNovel LY9 (Lymphocyte Antigen 9) Like Protein Accession Q9NQ25 Amino Acid Sequence Ser23 Met226, with C Avi tag and 8*His Expression System HEK293 Molecular Weight 35 45kDa (Reducing) Purity 95% by
Product Specification
| Species | Human |
| Synonyms | CS1，UNQ576/PRO1138，Novel Ly9，SLAM Family Member 7，Membrane Protein FOAP-12，CD2 Subset 1，Protein 19A，CD2-Like Receptor Activating Cytotoxic Cells，CD2-Like Receptor-Activating Cytotoxic Cells，19A24 Protein，19A，CD319 Antigen，Novel LY9 (Lymphocyte Antigen 9) Like Protein |
| Accession | Q9NQ25 |
| Amino Acid Sequence | Ser23-Met226, with C-Avi tag and 8*His |
| Expression System | HEK293 |
| Molecular Weight | 35-45kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Veillette, A. (2006) Immunol. Rev. 214:22. 2.Tovar, V. et al. (2002) Immunogenetics 54:394. 3.Murphy, J.J. et al. (2002) Biochem. J. 361:431. |
Background
SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. Mature mouse CRACC consists of a 202 amino acid (aa) extracellular domain (ECD) with one Ig-like V-set domain and one Ig-like C2-set domain, a 21 aa transmembrane segment, and an 88 aa cytoplasmic domain with two immunoreceptor tyrosine-based switch motifs ITSMs. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Mediates natural killer (NK) cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on the adapter SH2D1B. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.8 ★★★★★
Based on 11 reviews
Sort
Product Reviews
★★★★★ 5
Beneath the perfect surface
Format: Kindle
Yesteryear completely caught me off guard in the best possible way. What begins as a fascinating look into social media influence, curated perfection, and historical living slowly unfolds into something far deeper and far more emotional than I expected.
The storytelling was incredibly well done, especially the way the author balanced the polished modern influencer world against the harsh realities of 1800s frontier life. The transitions between timelines and perspectives were seamless, and by the end, every piece fit together in a way that completely redefined the story.
What made this especially compelling for me was how layered Natalie’s character felt. Her upbringing, family expectations, faith, public image, and the pressure to maintain perfection all shaped the choices she made throughout the story. Rather than feeling one-dimensional, she felt like someone slowly buckling under the weight of everything she believed she was supposed to be.
The emotional impact of this book surprised me. Beneath the historical elements and social media commentary is a story about identity, appearances, family, and the toll that constant performance can take on a person and those around them.
This is one of those books where the less you know going in, the better the experience will be. I expected an entertaining premise, but I ended up with a story that lingered long after I finished the final page.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 28, 2026
★★★★★ 3
About that twist…
Format: Kindle
SPOILER ALERT!
The thing about big, improbable twists in stories is that the less time you have to think about them, the better their effect. For fans of the classic TV show The Twilight Zone, it has always been clear that the half-hour shows were far better and far more punchy and memorable than their rather sad hour-long cousins. And a book has far, far more time to contemplate a twist than a TV show.
Unfortunately, despite some pointed observations by the author (narcissistic people are pretty much unlikable, cruelty and brutality give power to weak men, abused children very often cling to their abusers), the big, improbable twist in Yesteryear almost completely sinks the story.
The twist is the same one that sank M. Night Shyamalan’s 2004 movie The Village, and it fares no better here. Yes, people can and do live off the grid. But avoiding every single sign of civilization for years on end? Even if you’re not in a commercial flight path, there are such things as helicopters and small private planes, especially in remote areas. Perhaps people rarely stray onto private land in the wilderness, but once in a while, stray they do. And when that wilderness home was once widely publicized? Excuse me, but people are going to look for it.
This is all not to say that Yesteryear was not entertaining - it was. I read it in one sitting. The characters, as unlikable and unreliable as they are, were well drawn. A couple of the children were also quite believable, but the author’s excuse for the rest of the kids being cyphers was that their mother saw them as cyphers as well. Okay, that’s fair, but knowing them better would have enhanced the story for the reader.
This is certainly a promising book. It held my attention and was very well-written. But that twist - well, it sank M. Night Shyamalan, too.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 10, 2026
★★★★★ 4
Good read
Format: Hardcover
This book has been getting a lot of hype, and I can understand why. First, it is a very unique storyline. Very different plot. Second, the main character, Natalie, is totally unlikable. In fact, I would honestly say I loathed her. She has no likeable qualities whatsoever. I guess that is what makes you want to keep reading, to find out what happens to this nasty woman. That said, I admit I was confused at the end. I am still not sure what exactly happened to Natalie, how the situation came about, and how 10 years went by when Natalie seemed to only be telling a few months time. Was she delusional? Did she have a mental breakdown? I wish it was more clear as to what exactly happened.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 23, 2026
★★★★★ 5
What did i spend so much time reading??
Format: Kindle
Spoilers ahead This book makes me angry. A misogynistic fable that holds women as mothers as inherently either deeply flawed or as if some fairy tale perfect mother exists. I found the early parts of the novel quite funny. Thinking this poor woman why do people expect such crazy standards? Also social media influencers somehow we are to take for reality? It is entertaining and that's why we want to spend our time looking at it. It is a fantasy world. Yet that is somehow turned from something comical and poignant dissolving into madness where there can be a 16 year old that can take away your children for what I'm not sure. Filming them? Having nannies? And then again the next bunch for living off the grid? I get that this isn't going for realism. It ultimately became for me this poorly written satire maybe? Obviously what started as comically intriguing for me descended into one totally crazy crazy turn to the darkest of places. I recognize this was supposed to be some sort of cracked fairytale where nearly everyone is evil and/or mental but 30 years for child abuse? This is like a nightmare not a thriller. The book demonstrates a hatred for mothers. Just awful! It made me crave for a totally unrealistic thriller. I came to be entertained and left pissed off.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 13, 2026
★★★★★ 5
Excellent satire of tradition cult
Format: Kindle
I read this book in two days. I was eager to read it once I read the description in a Facebook post. I am a theologically conservative Christian frustrated with the tradition culture that has co-opted the faith. I see this in my social and social media circles quite a bit, and I was intrigued by a novel that took this movement to task.
Furthermore, I truly enjoy well done satire and farce. I have had a hard time finding these works written well in the past, so I was bracing myself to be disappointed. I am thankful to say, I wasn’t. I didn’t expect the novel to go the way it did (and no, I won’t post spoilers), but I literally laughed out loud a several points.
Let me compliment the author for one particular point: She doesn’t just blast the “tradwife” movement. Plenty of cultural movements and groups of people have their sins exploited. Rather than shooting a 12-gauge at religious conservatives, she takes a Tommy gun and hits a wide range of systems.
I do want to warn squeamish readers about another issue: The novel can be quite graphic at times, explicitly detailing the intimacy struggles with the main couple. It borders on the pornographic side, but not for titillation. It’s meant to show the dysfunction in the supposedly happy couple.
There were quite a few humorous moments, such as the protagonist enjoying the sounds of the chickens, only to grow wistful about their impending deaths so she can taste chicken broth. Or the protagonist’s evangelical mother reacting to her son-in-law’s purchase of a yoga mat.
I was a little disappointed in the resolution of the central issue, i.e., the time travel. But overall, the novel was an enjoyable read and worth your time.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 8, 2026