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Description
human bsep vesicle kit hek293Das Human BSEP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient die Bile Salt Export Pump (BSEP ABCB11) berexprimieren. BSEP ist der primre hepatische Efflux Transporter fr Gallensalze und ein zentrales Zielprotein in der Risikoabschtzung fr medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017) und EMA (2013) Leitlinien fr DDI Studien. Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich
Das Human BSEP Vesicle Kit enthält Inside-out Membranvesikel aus HEK293-Zellen, die transient die Bile Salt Export Pump (BSEP / ABCB11) überexprimieren. BSEP ist der primäre hepatische Efflux-Transporter für Gallensalze und ein zentrales Zielprotein in der Risikoabschätzung für medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017)- und EMA (2013) Leitlinien für DDI Studien.
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
Transporter-Profil
Name: BSEP, Bile Salt Export Pump, ABCB11, ATP-bindende Kassette Unterfamilie B Mitglied 11
Gen: ABCB11
ATP/AMP-Ratio: >10 (garantiert)
Gewebsexpression: Kanalikuläre Plasmamembran der Hepatozyten
Erkrankungen: Erbliche und medikamenteninduzierte Cholestase (DILI)
Bekannte Substrate: Taurocholat, Pravastatin, Taurolithocholyl-3-Sulfat, konjugierte monovalente Gallensalze
In stock: Human, Katze, Hund
Kit-Inhalt (100 Reaktionen)
- Vesikel-Vial (100 Reaktionen), BSEP überexprimierende HEK293-abgeleitete Vesikel
- AMP-ATP-Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Anwendungen
- allensalztransport-Inhibitionsstudien (Cholestase-Risikoabschätzung)
- Drug-Induced Liver Injury (DILI) Screening
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Substratidentifikation für hepatische Efflux-Transporter
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
Die Hemmung von BSEP ist ein etablierter Mechanismus der medikamenteninduzierten cholestatischen Leberschädigung. Die Bewertung der BSEP-Hemmung wird in den FDA (2017)- und EMA (2013)-DDI-Leitlinien als Teil des Transporter-Charakterisierungspakets für neue Molekülentitäten (NMEs) in der klinischen Entwicklung empfohlen.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
Verwandte Produkte
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
- Human MRP2 Vesicle Kit (C4PVK002) – for parallel hepatic efflux assessment
- Human BCRP Vesicle Kit (C4PVK006) – for complete efflux transporter panel
- ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
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4.8 ★★★★★
Based on 1792 reviews
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Product Reviews
★★★★★ 5
Great book
Format: Kindle
I absolutely feel in love with all 4 characters!!! The bedroom scenes were 🌋🌡🔥🔥🔥. I couldn't put this book down!!! I'm hooked for the whole series Book 2 here I come!!!!! Its a fun easy book and story to read!!
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Reviewed in the United States on October 4, 2024
★★★★★ 4
Fun with a late blooming omega
Format: Kindle
I like this book. The story is fun, cute, and sexy. There's just a little drama, some excellent, steamy scenes, and a fairly good relationship building storyline. I especially like how all the main characters are a bit older than the usual 20 somethings I tend to see in this kind of book.
Having said that, I wish there were more descriptions of the places, as well as the food in the fancy restaurant. I enjoyed the cocktails at the club, so I missed that kind of detail when Gray took Madison on a dinner date. I also wish there had been more interaction between Lucas and Madison, and Lucas and Rian. It felt a bit lopsided, with a focus on Rian, Madison, and Gray.
I wish it had been proofread - there are a lot of typos, but nothing too distracting.
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Reviewed in the United States on September 12, 2022
★★★★★ 3
Madison Deserved Better
Format: Kindle
Madison was a beta...except she wasn't any longer. She was a late presenting Omega. And she was struggling. She was tall and thin, not tiny and curvy. She was opinionated. She was everything an Omega was not. After suffering through her first heat, her friends took her to Ardor, a club where Omegas came to safely find Alphas. She's not expecting much but then she connects with a sexy beta. And when she meets his Alphas, they set her body on fire. Maybe, she's found her no-strings-attached heat pack. Maybe, she's found something more.
I could not connect with the characters in this book, so their story never resonated with me. And there was no love story; there was sex. Grey made it clear from the beginning that he had a true love and it was his beta boy, Rian. He went so far as to reassure Rian “Say the word, I’ll never touch her again. Lucas can put the babies in her. I only need you, beta boy”. So, Madison was there for babies, no emotions needed. Nice. No, thank you. I want the Omega to be the center of their world, not an incubator. Lucas and Rian weren't any better. After her heat, they let her leave. Not one of them made her feel valued. No one gave her a reason to stay or even offered a cuddle. And the sex didn't even come across as mind-blowing. Madison deserved better.
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Reviewed in the United States on March 11, 2025
★★★★★ 5
No breakup, very sweet, instalove
Format: Kindle
Omegaverse and doesn't disappoint! Sweet guys, newly Omega FMC. The boyfriends are boyfriends. What's not to love? No angst, no breakup.
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Reviewed in the United States on February 23, 2025
★★★★★ 4
Pretty Darn Good
Format: Kindle
So I’ve been on a omega kick and this definitely hit the spot. Madison was frustrating at times with how she acted towards Lucas, Gray, and Rian. It was like she said towards the end, she didn’t believe she deserved nice things.
It would have been nice to hear from her best friends again. They kind of were there in the beginning and the gone except for mention of text messages received from them. I feel like her friends would have been great help in encouraging Madison to go with the pack and never give Brent another chance because he was toxic.
I loved Rian. His personality was awesome. His humor. His ability to make Madison comfortable whenever she was feeling overwhelmed. And the fact he fell for her and she fell for him first. They are cute together.
I do feel like Lucas was the odd man out though. Like Lucas didn’t develop as much of a relationship with Madison. I would have really liked to see more development in the relationship between them. It was also the same with him and Rian. There is really no relationship displayed. Most of the relationship being displayed is between Rian and Gray.
Nevertheless, I loved reading about the dynamic that came to fruition during the entirety of this story. Madison finally got her happiness. And Brent finally got punched in the face. Everyone got exactly what they deserve.
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Reviewed in the United States on September 6, 2022